Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | TPMT | P51580 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319942 | 0.90 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8322445 | 0.89 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8270323 | 0.87 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4824534 | 0.83 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8270352 | 0.83 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4824530 | 0.83 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8322454 | 0.82 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8270539 | 0.81 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL4823369 | 0.81 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8268692 | 0.81 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |