Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.78 |
| ▸ | CDK8 | P49336 | 3/20 | 0.78 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.78 |
| ▸ | KIT | P10721 | 3/20 | 0.68 |
| ▸ | SGK1 | O00141 | 1/20 | 0.66 |
| ▸ | CDC7 | O00311 | 1/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
| ▸ | PRKACA | P17612 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.66 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.64 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320989 | 0.89 | AXL (0.83) | AXLCDK8TNIKKITSGK1 | |
| SCHEMBL8941685 | 0.88 | AXL (1.00) | AXLCDK8TNIKSGK1ROCK2 | |
| SCHEMBL12763289 | 0.87 | KIT (0.66) | AXLCDK8TNIKKITCDC7 | |
| SCHEMBL17319205 | 0.87 | KIT (0.69) | AXLCDK8TNIKKITCDC7 | |
| SCHEMBL8320902 | 0.86 | MAPK8 (0.67) | AXLCDK8TNIKKITSGK1 | |
| SCHEMBL29337149 | 0.84 | NTRK1 (0.90) | AXLCDK8TNIKKITSGK1 | |
| SCHEMBL12572765 | 0.84 | AXL (0.76) | AXLCDK8TNIKKITSGK1 | |
| SCHEMBL1857492 | 0.84 | AXL (0.76) | AXLCDK8TNIKKITSGK1 | |
| SCHEMBL3761281 | 0.84 | AXL (0.76) | AXLCDK8TNIKKITSGK1 | |
| SCHEMBL17319207 | 0.84 | KIT (0.69) | AXLCDK8TNIKKITSGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | AXL 3999/4885CDK8 360/4885TNIK 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.