Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MERTK | Q12866 | 2/20 | 0.52 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319961 | 0.87 | EGFR (0.58) | EGFRHTTERBB2HPGDSYK | |
| SCHEMBL8312571 | 0.87 | CSNK2A1 (0.60) | EGFRHTTERBB2HPGDMERTK | |
| SCHEMBL8315463 | 0.85 | EGFR (0.61) | EGFRHTTERBB2HPGDMERTK | |
| SCHEMBL8318401 | 0.85 | EGFR (0.56) | EGFRHTTERBB2HPGDBRAF | |
| SCHEMBL8321212 | 0.85 | EGFR (0.64) | EGFRHTTERBB2HPGDSYK | |
| SCHEMBL8315669 | 0.84 | EGFR (0.56) | EGFRHTTERBB2HPGDBRAF | |
| SCHEMBL23538175 | 0.83 | EGFR (0.53) | EGFRERBB2 | |
| SCHEMBL6999398 | 0.82 | SYK (0.53) | EGFRHTTERBB2HPGDMERTK | |
| SCHEMBL6999389 | 0.82 | SYK (0.53) | EGFRHTTERBB2HPGDMERTK | |
| SCHEMBL8317471 | 0.82 | EGFR (0.61) | EGFRHTTERBB2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |