Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | BRAF | P15056 | 12/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319810 | 0.92 | EGFR (0.57) | EGFRBRAFERBB2 | |
| SCHEMBL8314278 | 0.86 | EGFR (0.61) | EGFRERBB2 | |
| SCHEMBL8315976 | 0.84 | EGFR (0.55) | EGFRBRAFERBB2 | |
| SCHEMBL8319518 | 0.83 | EGFR (0.60) | EGFRBRAFERBB2 | |
| SCHEMBL8319990 | 0.83 | EGFR (0.54) | EGFRBRAF | |
| SCHEMBL8799689 | 0.80 | EGFR (0.55) | EGFRBRAF | |
| SCHEMBL8320421 | 0.80 | EGFR (0.65) | EGFRBRAF | |
| SCHEMBL8313771 | 0.80 | EGFR (0.65) | EGFRBRAF | |
| SCHEMBL8318909 | 0.80 | BRAF (0.53) | EGFRBRAF | |
| SCHEMBL8316302 | 0.79 | EGFR (0.59) | EGFRBRAFERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |