Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | BRAF | P15056 | 10/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318906 | 0.91 | ABCG2 (0.54) | SRCBRAFABCG2EGFR | |
| SCHEMBL8318621 | 0.89 | ABCG2 (0.52) | SRCBRAFABCG2EGFR | |
| SCHEMBL6995080 | 0.85 | BRAF (0.49) | BRAF | |
| SCHEMBL8314033 | 0.83 | ABCG2 (0.52) | BRAFABCG2 | |
| SCHEMBL8317331 | 0.83 | BRAF (0.56) | BRAFCTSLCTSBCTSSCTSK | |
| SCHEMBL8319713 | 0.83 | EGFR (0.66) | SRCBRAFEGFR | |
| SCHEMBL8320360 | 0.83 | BRAF (0.56) | BRAFEGFR | |
| SCHEMBL8315227 | 0.83 | EGFR (0.66) | BRAFEGFR | |
| SCHEMBL8316477 | 0.83 | BRAF (0.64) | SRCBRAFEGFR | |
| SCHEMBL8316766 | 0.82 | EGFR (0.74) | BRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |