Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403690 | 0.74 | F10 (0.55) | — | |
| SCHEMBL8324002 | 0.74 | HDAC1 (0.59) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL8325149 | 0.74 | MEN1 (0.52) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL8322744 | 0.73 | HDAC1 (0.52) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL8321831 | 0.71 | HDAC1 (0.50) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL8319546 | 0.71 | HDAC1 (0.67) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL16148291 | 0.71 | GAA (0.52) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL8325188 | 0.71 | HDAC1 (0.49) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL8319423 | 0.71 | HDAC1 (0.49) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL8320037 | 0.70 | HDAC1 (0.72) | HDAC1HDAC8HDAC3HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |