Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.85 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.85 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.85 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.85 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 13/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9425430 | 0.93 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL8471230 | 0.92 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL13350282 | 0.84 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL8333755 | 0.84 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL8798987 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL236171 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DHTT | |
| Hydrochloric Acid SCHEMBL9425361 | 0.79 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL8799489 | 0.75 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL8801127 | 0.75 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL8798834 | 0.75 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004067006-A1 | COMBINATION OF A PDE IV INHIBITOR AND A TNF-ALPHA ANTAGONIST | PHARMACIA CORPORATION (US) | 2004-08-12 | — | — | WO | disclosed |