Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.55 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.55 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325723 | 0.89 | PTGER1 (0.59) | MEN1KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL8324167 | 0.88 | PTGER1 (0.51) | MEN1KMT2AKDM4EPTGER1PTGER4 | |
| SCHEMBL8326018 | 0.88 | PTGER1 (0.51) | MEN1KMT2AKDM4EPTGER1PTGER4 | |
| SCHEMBL8675775 | 0.87 | PTGER1 (0.56) | MEN1KMT2AKDM4EPTGER1PTGER4 | |
| SCHEMBL8325792 | 0.86 | PTGER1 (0.60) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8319855 | 0.85 | PTGER1 (0.59) | MEN1KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL8321834 | 0.85 | PTGER1 (0.59) | MEN1KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL8323803 | 0.84 | PTGER1 (0.51) | MEN1KMT2AKDM4EPTGER1PTGER4 | |
| SCHEMBL8319879 | 0.84 | PTGER1 (0.58) | MEN1KMT2APTGER1PTGER4PTGER3 | |
| SCHEMBL8318734 | 0.84 | PTGER1 (0.58) | PTGER1PTGER4PTGER3PTGER2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |