Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.65 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326636 | 0.77 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL8321440 | 0.77 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL14899541 | 0.73 | DPP4 (0.55) | DPP4DPP8DPP9 | |
| SCHEMBL8320687 | 0.72 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL27693121 | 0.71 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL2757918 | 0.71 | DPP4 (0.39) | DPP4CYP1A2MAPK1 | |
| SCHEMBL387066 | 0.71 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL18410820 | 0.71 | DPP4 (0.46) | DPP4CYP1A2MAPK1 | |
| SCHEMBL3298428 | 0.66 | DPP4 (0.37) | DPP4CYP1A2MAPK1 | |
| SCHEMBL4376489 | 0.65 | DPP4 (0.58) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553937-B1 | GLYCINENITRILE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | BRISTOL MYERS SQUIBB CO (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2004037181-A2 | GLYCINENITRILE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-05-06 | — | — | WO | disclosed |