Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 20/20 | 0.84 |
| ▸ | CDK2 | P24941 | 3/20 | 0.84 |
| ▸ | CDK4 | P11802 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486988 | 0.92 | GSK3B (0.89) | GSK3BCDK2CDK4 | |
| SCHEMBL4477642 | 0.91 | GSK3B (1.00) | GSK3BCDK2CDK4 | |
| SCHEMBL4492120 | 0.91 | GSK3B (1.00) | GSK3BCDK2CDK4 | |
| SCHEMBL4475404 | 0.89 | GSK3B (1.00) | GSK3BCDK2CDK4 | |
| Gw828525X SCHEMBL4472561 | 0.88 | GSK3B (0.85) | GSK3BCDK2 | |
| SCHEMBL4491810 | 0.84 | GSK3B (0.82) | GSK3BCDK2 | |
| SCHEMBL4475079 | 0.80 | GSK3B (1.00) | GSK3BCDK2CDK4 | |
| Gw827102X SCHEMBL4474674 | 0.80 | GSK3B (1.00) | GSK3BCDK2CDK4 | |
| Gw829906X SCHEMBL4476648 | 0.80 | GSK3B (1.00) | GSK3BCDK2CDK4 | |
| SCHEMBL4474335 | 0.79 | GSK3B (0.91) | GSK3BCDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582630-B2 | Pyradazine compounds as GSK-3 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-01 | — | — | US | disclosed |
| WO-2004035588-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |