Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.57 |
| ▸ | CDK4 | P11802 | 9/20 | 0.57 |
| ▸ | EIF2AK2 | P19525 | 5/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14011240 | 0.96 | CDK2 (0.54) | CDK2CDK4EIF2AK2KCNH2CAMK2D | |
| SCHEMBL8320691 | 0.91 | CDK4 (0.55) | CDK2CDK4EIF2AK2CAMK2DJAK2 | |
| SCHEMBL14011239 | 0.87 | CDK4 (0.52) | CDK2CDK4EIF2AK2CAMK2DJAK2 | |
| SCHEMBL8321179 | 0.84 | CDK4 (0.57) | CDK2CDK4EIF2AK2CAMK2DJAK2 | |
| SCHEMBL14011244 | 0.82 | CDK4 (0.57) | CDK2CDK4EIF2AK2CAMK2DJAK2 | |
| SCHEMBL14011243 | 0.80 | SYK (0.54) | CDK2CDK4 | |
| SCHEMBL8316804 | 0.80 | CDK4 (0.59) | CDK2CDK4EIF2AK2CAMK2DJAK2 | |
| SCHEMBL13597612 | 0.79 | CDK4 (0.52) | CDK2CDK4EIF2AK2CAMK2DJAK2 | |
| SCHEMBL14011242 | 0.79 | CDK4 (0.54) | CDK2CDK4EIF2AK2CAMK2DJAK2 | |
| SCHEMBL8316906 | 0.79 | CDK4 (0.58) | CDK2CDK4EIF2AK2CAMK2DJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606284-B1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2009-12-02 | — | — | EP | disclosed |
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| WO-2004083203-A1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-30 | — | — | WO | disclosed |