Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 10/20 | 0.64 |
| ▸ | DRD3 | P35462 | 8/20 | 0.64 |
| ▸ | DRD2 | P14416 | 7/20 | 0.64 |
| ▸ | HTR2A | P28223 | 6/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388152 | 0.88 | DRD4 (0.80) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL1387944 | 0.87 | DRD4 (0.58) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL1388185 | 0.86 | DRD4 (0.59) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL1388022 | 0.86 | DRD4 (0.59) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL1388014 | 0.85 | DRD4 (0.65) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL1388235 | 0.82 | DRD4 (0.56) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL1388183 | 0.82 | DRD4 (0.56) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL9396940 | 0.81 | DRD4 (0.51) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL8319893 | 0.76 | DRD4 (0.58) | DRD4DRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL1388109 | 0.76 | DRD4 (0.60) | DRD4DRD3DRD2HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687267-B1 | PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR | MERCK SHARP & DOHME (GB) | 1999-09-01 | — | — | EP | claimed |
| EP-0687267-B1 | PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR | MERCK SHARP & DOHME (GB) | 1999-09-01 | — | — | EP | disclosed |
| US-5700809-A | Pyrrolo-pyridine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0687267-A1 | PYRROLO-PYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-12-20 | — | — | EP | disclosed |
| WO-1994020459-A2 | PYRROLO-PYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |