Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 18/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322809 | 1.00 | DRD4 (0.40) | DRD4DRD3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8328089 | 0.91 | DRD4 (0.41) | DRD4DRD3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8328088 | 0.91 | DRD4 (0.41) | DRD4DRD3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8327781 | 0.91 | DRD4 (0.43) | DRD4DRD3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8327784 | 0.91 | DRD4 (0.43) | DRD4DRD3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8329839 | 0.85 | DRD4 (0.41) | DRD4CYP1A2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL8329875 | 0.85 | DRD4 (0.43) | DRD4DRD3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8329877 | 0.85 | DRD4 (0.43) | DRD4DRD3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8330688 | 0.85 | DRD4 (0.47) | DRD4DRD3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8327400 | 0.85 | DRD4 (0.41) | DRD4DRD3CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |