Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PPIA | P62937 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322849 | 1.00 | KMT2A (0.56) | KMT2AMAPTLMNARAB9AL3MBTL1 | |
| SCHEMBL8323855 | 0.89 | PPIA (0.54) | KMT2AMAPTPPIAALDH1A1RXRA | |
| SCHEMBL8323857 | 0.89 | PPIA (0.54) | KMT2AMAPTPPIAALDH1A1RXRA | |
| SCHEMBL8324434 | 0.88 | KMT2A (0.55) | KMT2AMAPTLMNARAB9AL3MBTL1 | |
| SCHEMBL8324432 | 0.88 | KMT2A (0.55) | KMT2AMAPTLMNARAB9AL3MBTL1 | |
| SCHEMBL8523359 | 0.85 | KMT2A (0.62) | KMT2AMAPTLMNARAB9AL3MBTL1 | |
| SCHEMBL8523361 | 0.85 | KMT2A (0.62) | KMT2AMAPTLMNARAB9AL3MBTL1 | |
| SCHEMBL30078173 | 0.83 | KMT2A (0.63) | KMT2AMAPTLMNARAB9AL3MBTL1 | |
| SCHEMBL15065516 | 0.83 | KMT2A (0.63) | KMT2AMAPTLMNARAB9AL3MBTL1 | |
| SCHEMBL8677984 | 0.79 | KMT2A (0.49) | KMT2ALMNAPPIAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |