Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.45 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154573 | 0.88 | PTGER1 (0.52) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL3035265 | 0.84 | MAPT (0.50) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL20359857 | 0.84 | MAPT (0.49) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL19999733 | 0.83 | CCNB2 (0.48) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL7229340 | 0.81 | CDK4 (0.68) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL19999728 | 0.81 | HDAC8 (0.48) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL7229336 | 0.81 | CDK4 (0.68) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL686650 | 0.80 | MAPT (0.58) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL14228414 | 0.78 | MAPT (0.56) | MAPTMAPK1TDP1L3MBTL1STAT3 | |
| SCHEMBL28505728 | 0.77 | PTGER1 (0.43) | MAPTMAPK1TDP1L3MBTL1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |