Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.55 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.55 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323448 | 1.00 | PTGER1 (0.55) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8320332 | 0.85 | PTGER4 (0.54) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8320330 | 0.85 | PTGER4 (0.54) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL7774973 | 0.84 | KMT2A (0.62) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL7774977 | 0.84 | KMT2A (0.62) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8319700 | 0.80 | PTGER4 (0.53) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8319694 | 0.80 | PTGER4 (0.53) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8322341 | 0.80 | PTGER4 (0.53) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8327004 | 0.80 | PTGER4 (0.53) | PTGER1PTGER4PTGER3PTGER2ALDH1A1 | |
| SCHEMBL8322642 | 0.80 | PTGER4 (0.53) | PTGER1PTGER4PTGER3PTGER2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0925298-A1 | SUBSTITUTED 6,6-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-30 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| WO-1998008846-A1 | SUBSTITUTED 6,6-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-03-05 | — | — | WO | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |