Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323492 | 1.00 | PDE4B (0.45) | PDE4BCTSDBACE1CTSLKMT2A | |
| SCHEMBL6947042 | 0.94 | PDE4B (0.44) | PDE4BCTSDBACE1CTSLKMT2A | |
| SCHEMBL8326625 | 0.88 | SMN1; SMN2 (0.47) | PDE4BCTSLKMT2AL3MBTL1HTT | |
| SCHEMBL18860228 | 0.88 | SMN1; SMN2 (0.47) | PDE4BCTSLKMT2AL3MBTL1HTT | |
| SCHEMBL29364160 | 0.88 | SMN1; SMN2 (0.47) | PDE4BCTSLKMT2AL3MBTL1HTT | |
| SCHEMBL12683556 | 0.86 | PDE4B (0.48) | PDE4BCTSLKMT2AL3MBTL1HTT | |
| SCHEMBL26627091 | 0.85 | PDE4B (0.46) | PDE4BCTSLKMT2AL3MBTL1HTT | |
| SCHEMBL30210320 | 0.84 | PDE4B (0.47) | PDE4BCTSLKMT2AL3MBTL1HTT | |
| SCHEMBL31634703 | 0.84 | PDE4B (0.47) | PDE4BCTSLKMT2AL3MBTL1HTT | |
| SCHEMBL4372291 | 0.81 | SMN1; SMN2 (0.49) | PDE4BCTSLKMT2AL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641339-B1 | AZASPIRO QUINOLONE ANTIBACTERIAL AGENTS | PFIZER (US) | 1999-09-15 | — | — | EP | disclosed |
| US-5407943-A | Azaspiro quinolone antibacterial agents | PFIZER INC. (US) | 1995-04-18 | — | — | US | disclosed |