Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.51 |
| ▸ | CLK1 | P49759 | 5/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313417 | 0.85 | CDK8 (0.73) | CDK8DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL13753932 | 0.84 | CDK8 (0.58) | CDK8DYRK1ACDK2CCNT1CCNA2 | |
| SCHEMBL8320362 | 0.82 | CDK8 (0.77) | CDK8DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL13745364 | 0.82 | CDK8 (0.56) | CDK8DYRK1ACDK2CCNT1CCNA2 | |
| SCHEMBL1487549 | 0.81 | CDK8 (0.67) | CDK8DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL8320115 | 0.81 | CDK8 (0.84) | CDK8DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL8324861 | 0.77 | CDK8 (0.85) | CDK8DYRK1ACDK2CCNT1CCNA2 | |
| SCHEMBL13745464 | 0.77 | CDK8 (1.00) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL1516669 | 0.77 | CDK8 (0.76) | CDK8DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL12763457 | 0.76 | CDK8 (0.79) | CDK8DYRK1ACLK1DYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |