Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.57 |
| ▸ | PDE4A | P27815 | 9/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | TNF | P01375 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1143560 | 0.92 | PDE4B (0.58) | PDE4BPDE4CPDE4DPDE4AHTR2B | |
| SCHEMBL1144002 | 0.92 | PDE4B (0.69) | PDE4BPDE4CPDE4DPDE4AHTR2B | |
| SCHEMBL1144312 | 0.90 | PDE4B (0.58) | PDE4BPDE4CPDE4DPDE4AHTR2B | |
| SCHEMBL1144026 | 0.84 | PDE4B (0.70) | PDE4BPDE4CPDE4DPDE4AHTR2B | |
| SCHEMBL1144131 | 0.82 | PDE4B (0.62) | PDE4BPDE4CPDE4DPDE4AHTR2B | |
| SCHEMBL1143589 | 0.82 | PDE4B (0.72) | PDE4BPDE4CPDE4DPDE4AHTR2B | |
| SCHEMBL21494522 | 0.81 | PDE4B (0.73) | PDE4BPDE4CPDE4DPDE4AHTR2B | |
| SCHEMBL1143705 | 0.81 | PDE4B (0.84) | PDE4BPDE4CPDE4DPDE4AHTR2B | |
| SCHEMBL1143730 | 0.81 | TNF (0.51) | PDE4BPDE4CPDE4DPDE4ATNF | |
| SCHEMBL1143995 | 0.81 | PDE4B (0.70) | PDE4BPDE4CPDE4DPDE4AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004060313-A2 | FLUOROALKOXY-SUBSTITUTED 1, 3-DIHYDRO-ISOINDOLYL COMPOUNDS AND THEIR PHARMACEUTICAL USES | CELGENE CORPORATION (US) | 2004-07-22 | — | — | WO | disclosed |