Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27546673 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6250930 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6640822 | 0.77 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL18951978 | 0.77 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11KIT | |
| SCHEMBL6641332 | 0.76 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL6643267 | 0.76 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL6643643 | 0.75 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6640941 | 0.75 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL1994242 | 0.75 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11CYP3A4 | |
| SCHEMBL6645674 | 0.75 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948495-A1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | Amgen Inc., (US) | 1999-10-13 | — | — | EP | claimed |
| WO-1998022457-A1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | AMGEN INC. (US) | 1998-05-28 | — | — | WO | claimed |