Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327738 | 0.91 | MAPT (0.41) | MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8325775 | 0.86 | MAPT (0.56) | MAPTSMN1; SMN2THRBALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8330855 | 0.85 | MAPT (0.56) | MAPTSMN1; SMN2THRBALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8326619 | 0.85 | MAPT (0.54) | MAPTSMN1; SMN2THRBALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8330455 | 0.84 | MAPT (0.55) | MAPTSMN1; SMN2THRBALDH1A1LMNA | |
| SCHEMBL8329418 | 0.84 | MAPT (0.57) | MAPTSMN1; SMN2THRBLMNADYRK1A | |
| Hydrochloric Acid SCHEMBL8326208 | 0.83 | MAPT (0.56) | MAPTSMN1; SMN2THRBLMNADYRK1A | |
| SCHEMBL8326159 | 0.83 | MAPT (0.52) | MAPTSMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8330067 | 0.82 | MAPT (0.51) | MAPTSMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8324456 | 0.82 | MAPT (0.55) | MAPTSMN1; SMN2THRBLMNADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| EP-0705260-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |