Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 13/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325688 | 1.00 | PTGER1 (0.56) | PTGER1MRGPRX4PTGER4PTGER3PTGER2 | |
| SCHEMBL8324739 | 1.00 | PTGER1 (0.56) | PTGER1MRGPRX4PTGER4PTGER3PTGER2 | |
| SCHEMBL8327463 | 0.91 | PTGER1 (0.54) | PTGER1MRGPRX4PTGER4PTGER3PTGER2 | |
| SCHEMBL8327466 | 0.91 | PTGER1 (0.54) | PTGER1MRGPRX4PTGER4PTGER3PTGER2 | |
| SCHEMBL8321952 | 0.84 | GCK (0.57) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8321955 | 0.84 | GCK (0.57) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL15726358 | 0.83 | MRGPRX4 (0.60) | PTGER1MRGPRX4CYP2C9HPGDRXRA | |
| SCHEMBL8677610 | 0.82 | PTGER1 (0.58) | PTGER1MRGPRX4PTGER4PTGER3PTGER2 | |
| SCHEMBL8409624 | 0.80 | MRGPRX4 (0.66) | PTGER1MRGPRX4PTGER4PTGER3PTGER2 | |
| SCHEMBL8321739 | 0.80 | MRGPRX4 (0.66) | PTGER1MRGPRX4PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |