Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.81 |
| ▸ | EDNRB | P24530 | 14/20 | 0.81 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | DHPS | P49366 | 1/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.59 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091645 | 0.92 | EDNRA (0.86) | EDNRAEDNRB | |
| SCHEMBL9090531 | 0.91 | EDNRA (0.85) | EDNRAEDNRB | |
| SCHEMBL8320276 | 0.89 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL8327812 | 0.89 | EDNRA (0.82) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL8325776 | 0.89 | EDNRA (0.81) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL9091526 | 0.88 | EDNRA (0.80) | EDNRAEDNRB | |
| SCHEMBL8323551 | 0.86 | EDNRA (0.82) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL9090806 | 0.84 | EDNRA (0.74) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7852939 | 0.82 | EDNRA (0.73) | EDNRAEDNRB | |
| SCHEMBL9092658 | 0.82 | EDNRA (0.86) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | claimed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |