Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.53 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8580284 | 0.78 | HTR1B (0.58) | HTR1BHTR2BGPR65CRHR1DYRK1A | |
| SCHEMBL5750446 | 0.78 | HTR1B (0.67) | HTR1BHTR2BGPR65CRHR1DYRK1A | |
| Bromide SCHEMBL5750327 | 0.76 | HTR1B (0.53) | HTR1BHTR2BGPR65ALOX5APFEN1 | |
| Bromide SCHEMBL5750336 | 0.75 | HTR1B (0.52) | HTR1BHTR2BGPR65 | |
| SCHEMBL5746220 | 0.73 | HTR1B (0.53) | HTR1BHTR2BGPR65 | |
| Bromide SCHEMBL8386216 | 0.73 | HTR1B (0.58) | HTR1BHTR2BGPR65 | |
| SCHEMBL5745868 | 0.73 | HTR1B (0.58) | HTR1BHTR2BGPR65DYRK1A | |
| SCHEMBL5749062 | 0.73 | HTR1B (0.60) | HTR1BHTR2BGPR65CRHR1DYRK1A | |
| Hydrochloric Acid SCHEMBL5750473 | 0.71 | HTR1B (0.58) | HTR1BHTR2BGPR65 | |
| SCHEMBL5747074 | 0.71 | HTR1B (0.58) | HTR1BHTR2BGPR65DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901474-A1 | ARYL PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044326-A1 | ARYL PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-27 | — | — | WO | disclosed |