Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.45 |
| ▸ | EDNRB | P24530 | 12/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328960 | 0.95 | EDNRA (0.45) | EDNRAEDNRBALDH1A1MEN1KMT2A | |
| SCHEMBL9091512 | 0.93 | EDNRA (0.44) | EDNRAEDNRBALDH1A1MEN1KMT2A | |
| SCHEMBL8322011 | 0.90 | EDNRA (0.48) | EDNRAEDNRBMAPTLMNAGLA | |
| SCHEMBL8323249 | 0.88 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL8324961 | 0.86 | EDNRA (0.58) | EDNRAEDNRBALDH1A1MEN1KMT2A | |
| SCHEMBL8324911 | 0.83 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL9152792 | 0.82 | EDNRA (0.54) | EDNRAEDNRBALDH1A1MEN1KMT2A | |
| SCHEMBL9152112 | 0.82 | EDNRA (0.54) | EDNRAEDNRBALDH1A1MEN1KMT2A | |
| SCHEMBL8328509 | 0.82 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL9154629 | 0.82 | EDNRA (0.51) | EDNRAEDNRBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | claimed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |