Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 17/20 | 0.83 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.65 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.65 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006865 | 0.91 | PLA2G1B (1.00) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7013081 | 0.91 | PLA2G1B (0.70) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7011159 | 0.90 | PLA2G1B (0.85) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL8325195 | 0.88 | PLA2G1B (0.88) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7017189 | 0.88 | PLA2G1B (0.84) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7010344 | 0.87 | PLA2G1B (0.79) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7051145 | 0.86 | PLA2G1B (0.84) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7008447 | 0.85 | PLA2G1B (0.71) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7011683 | 0.85 | PLA2G1B (0.85) | PLA2G1BPLA2G2APLA2G2EPLA2G5 | |
| SCHEMBL7010777 | 0.84 | PLA2G1B (0.84) | PLA2G1BPLA2G2APLA2G2EPLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |