Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.51 |
| ▸ | EDNRB | P24530 | 4/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329173 | 0.95 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL9282162 | 0.91 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL8324547 | 0.90 | EDNRA (0.63) | EDNRAEDNRB | |
| SCHEMBL8329196 | 0.88 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL9092381 | 0.86 | EDNRA (0.58) | EDNRAEDNRB | |
| SCHEMBL8327032 | 0.86 | EDNRA (0.46) | EDNRAEDNRB | |
| SCHEMBL8324859 | 0.85 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL8326215 | 0.84 | EDNRA (0.52) | EDNRAEDNRBPIK3CG | |
| SCHEMBL8323894 | 0.84 | EDNRA (0.47) | EDNRAEDNRB | |
| SCHEMBL8327303 | 0.84 | EDNRA (0.57) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | claimed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |