Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855363 | 0.76 | KDM4E (0.50) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL30324482 | 0.76 | KDM4E (0.50) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL13180855 | 0.76 | AURKA (0.46) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL14506261 | 0.75 | AURKA (0.44) | AURKAPARP1FEN1ALDH1A1PDK2 | |
| SCHEMBL22793031 | 0.74 | AURKA (0.43) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL8324581 | 0.73 | AURKA (0.46) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL28329874 | 0.73 | AXL (0.47) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL21115235 | 0.73 | AURKA (0.46) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL24354877 | 0.72 | AURKA (0.42) | AURKAPARP1FEN1NPC1HSP90AA1 | |
| SCHEMBL7976276 | 0.72 | KDM4E (0.46) | AURKAPARP1FEN1NPC1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |