Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328553 | 1.00 | KCNH2 (0.61) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8328781 | 0.91 | KCNH2 (0.51) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8326180 | 0.91 | KCNH2 (0.51) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8331977 | 0.91 | KCNH2 (0.51) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8332219 | 0.90 | KCNH2 (0.49) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8329101 | 0.90 | KCNH2 (0.49) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8332205 | 0.88 | KCNH2 (0.72) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8324629 | 0.88 | KCNH2 (0.72) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8331341 | 0.88 | KCNH2 (0.72) | KCNH2POLBCACNA1FMAPK1CACNA1D | |
| SCHEMBL8569407 | 0.86 | KCNH2 (0.44) | KCNH2POLBCACNA1FMAPK1CACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559774-B1 | INDIVIDUAL STEREOISOMERS OF 7- 3-(1-AMINOALKYL)-1-PYRROLIDINYL]-QUINOLONES AND NAPHTHYRIDONES AS ANTIBACTERIAL AGENTS | WARNER LAMBERT CO (US) | 1999-07-07 | — | — | EP | claimed |