Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 16/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.61 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.61 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | PRKACA | P17612 | 1/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.61 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.61 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.61 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328726 | 0.91 | PRKCI (0.68) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| SCHEMBL6936131 | 0.89 | PRKCI (0.63) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| SCHEMBL6936127 | 0.89 | PRKCI (0.63) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| Hydrochloric Acid SCHEMBL6934870 | 0.88 | PRKCI (0.62) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| Hydrochloric Acid SCHEMBL6934877 | 0.88 | PRKCI (0.62) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| Hydrochloric Acid SCHEMBL6934873 | 0.88 | PRKCI (0.62) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| SCHEMBL6931267 | 0.87 | PRKCI (0.79) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| SCHEMBL6931274 | 0.87 | PRKCI (0.79) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| SCHEMBL6931272 | 0.87 | PRKCI (0.79) | PRKCIMAPK14MAPK9MAPK13MAP4K4 | |
| Hydrochloric Acid SCHEMBL6934785 | 0.86 | PRKCI (0.77) | PRKCIMAPK14MAPK9MAPK13MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |