Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.46 |
| ▸ | EDNRB | P24530 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9092023 | 0.87 | EDNRA (0.50) | EDNRAEDNRB | |
| SCHEMBL8327090 | 0.86 | EDNRA (0.47) | EDNRAEDNRB | |
| SCHEMBL8326049 | 0.86 | EDNRA (0.49) | EDNRAEDNRBLMNAGLA | |
| SCHEMBL8326690 | 0.86 | EDNRA (0.46) | EDNRAEDNRBLMNAGLA | |
| SCHEMBL8323957 | 0.85 | EDNRA (0.48) | EDNRAEDNRBLMNAGLA | |
| SCHEMBL8322713 | 0.85 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL8322011 | 0.85 | EDNRA (0.48) | EDNRAEDNRBLMNAGLA | |
| SCHEMBL8325897 | 0.84 | EDNRA (0.48) | EDNRAEDNRB | |
| SCHEMBL8328455 | 0.84 | EDNRA (0.49) | EDNRAEDNRB | |
| SCHEMBL8322059 | 0.83 | EDNRA (0.56) | EDNRAEDNRBLMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | claimed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |