Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330075 | 0.88 | MAPK1 (0.49) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| SCHEMBL3949682 | 0.84 | MAPK1 (0.46) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| SCHEMBL8326726 | 0.83 | MAPK1 (0.45) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| SCHEMBL1225868 | 0.79 | TDP1 (0.56) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| SCHEMBL1605423 | 0.78 | MAPK1 (0.48) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| SCHEMBL9394785 | 0.77 | MAPK1 (0.47) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL8694159 | 0.76 | MAPK1 (0.46) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| SCHEMBL22176173 | 0.76 | MAPK1 (0.46) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| SCHEMBL8329737 | 0.75 | MAPK1 (0.48) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 | |
| SCHEMBL6644426 | 0.75 | TDP1 (0.48) | MAPK1SMN1; SMN2TDP1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |