Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.75 |
| ▸ | PDE4A | P27815 | 3/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13350269 | 1.00 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4CATM | |
| SCHEMBL7209210 | 1.00 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4CATM | |
| Hydrochloric Acid SCHEMBL8390741 | 0.99 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CATM | |
| Hydrochloric Acid SCHEMBL8390738 | 0.99 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CATM | |
| Hydrochloric Acid SCHEMBL7207679 | 0.97 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CATM | |
| Hydrochloric Acid SCHEMBL7207684 | 0.97 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CATM | |
| SCHEMBL7211517 | 0.90 | PDE4D (0.74) | PDE4DPDE4APDE4BPDE4CSSTR5 | |
| SCHEMBL7207660 | 0.90 | PDE4D (0.74) | PDE4DPDE4APDE4BPDE4CSSTR5 | |
| SCHEMBL3555816 | 0.90 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CSSTR5 | |
| SCHEMBL6440046 | 0.90 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4CSSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |