Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 13/20 | 0.69 |
| ▸ | RARA | P10276 | 12/20 | 0.69 |
| ▸ | RARB | P10826 | 11/20 | 0.69 |
| ▸ | RXRA | P19793 | 7/20 | 0.61 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.50 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.50 |
| ▸ | HNF4A | P41235 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565040 | 1.00 | RARG (0.69) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL9095816 | 0.86 | RARG (0.75) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL10556851 | 0.81 | RARB (1.00) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL10556841 | 0.81 | RARB (1.00) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL10565288 | 0.81 | RARB (0.53) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL2240683 | 0.80 | RARB (0.64) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL7799798 | 0.80 | RARG (0.48) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL7802962 | 0.80 | RARG (0.48) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL10693731 | 0.78 | RARB (0.84) | RARGRARARARBRXRACYP26A1 | |
| SCHEMBL10693727 | 0.78 | RARB (0.84) | RARGRARARARBRXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5917082-A | 2,4-pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN SALES, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5817836-A | 2,4-pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN (US) | 1998-10-06 | — | — | US | disclosed |
| US-5780647-A | 2,4-Pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN (US) | 1998-07-14 | — | — | US | disclosed |
| US-5675033-A | FOR TREATMENT OF SKIN DISORDERS | ALLERGAN (US) | 1997-10-07 | — | — | US | disclosed |