Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.68 |
| ▸ | HTR2A | P28223 | 8/20 | 0.68 |
| ▸ | HTR7 | P34969 | 8/20 | 0.68 |
| ▸ | DRD3 | P35462 | 6/20 | 0.68 |
| ▸ | DRD2 | P14416 | 5/20 | 0.68 |
| ▸ | HTR1A | P08908 | 5/20 | 0.68 |
| ▸ | HTR6 | P50406 | 5/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | HTR2C | P28335 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197306 | 0.87 | HTR2A (0.67) | DRD4HTR2AHTR7DRD3DRD2 | |
| SCHEMBL9394011 | 0.83 | DRD4 (0.74) | DRD4HTR2AHTR7DRD3DRD2 | |
| SCHEMBL5198398 | 0.83 | DRD4 (0.74) | DRD4HTR2AHTR7DRD3DRD2 | |
| L-745870 SCHEMBL29496328 | 0.81 | DRD4 (1.00) | DRD4HTR2AHTR7DRD3DRD2 | |
| L-745870 SCHEMBL1059886 | 0.81 | DRD4 (1.00) | DRD4HTR2AHTR7DRD3DRD2 | |
| SCHEMBL8858033 | 0.81 | DRD4 (0.78) | DRD4HTR2AHTR7DRD3DRD2 | |
| L-745870 SCHEMBL2031550 | 0.80 | DRD4 (1.00) | DRD4HTR2AHTR7DRD3DRD2 | |
| L-745870 SCHEMBL29692927 | 0.80 | DRD4 (1.00) | DRD4HTR2AHTR7DRD3DRD2 | |
| SCHEMBL5399421 | 0.79 | DRD4 (1.00) | DRD4HTR2AHTR7DRD3DRD2 | |
| SCHEMBL5382639 | 0.78 | DRD4 (0.76) | DRD4HTR2AHTR7DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999000386-A1 | DOPAMINE D4 RECEPTOR LIGANDS | RESOLUTION PHARMACEUTICALS INC. (CA) | 1999-01-07 | — | — | WO | claimed |
| WO-1999000386-A1 | DOPAMINE D4 RECEPTOR LIGANDS | RESOLUTION PHARMACEUTICALS INC. (CA) | 1999-01-07 | — | — | WO | disclosed |