Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 11/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961833 | 0.91 | DHODH (0.38) | DHODHSMN1; SMN2LMNACYP2C19KDM4E | |
| SCHEMBL7962627 | 0.90 | DHODH (0.37) | DHODHSMN1; SMN2LMNACYP2C19MAPT | |
| SCHEMBL8328807 | 0.89 | DHODH (0.39) | DHODHSMN1; SMN2LMNAIDO1CYP2C19 | |
| SCHEMBL7963830 | 0.88 | DHODH (0.36) | DHODHLMNAKMT2AIDO1CYP2C19 | |
| SCHEMBL8328134 | 0.87 | DHODH (0.44) | DHODHIDO1 | |
| SCHEMBL8328157 | 0.86 | DHODH (0.38) | DHODHSMN1; SMN2LMNAIDO1CYP2C19 | |
| SCHEMBL8329854 | 0.84 | DHODH (0.36) | DHODHSMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL8326689 | 0.84 | DHODH (0.36) | DHODHSMN1; SMN2LMNAIDO1POLB | |
| SCHEMBL7952437 | 0.83 | DHODH (0.34) | DHODHSMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL7965560 | 0.81 | HPGD (0.32) | DHODHSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | claimed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | claimed |