Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8328440 | 0.99 | MAPT (0.54) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| SCHEMBL8559604 | 0.93 | MAPT (0.62) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| SCHEMBL8326891 | 0.93 | MAPT (0.55) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| Hydrochloric Acid SCHEMBL8561142 | 0.92 | MAPT (0.61) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| SCHEMBL8323960 | 0.92 | MAPT (0.54) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| Hydrochloric Acid SCHEMBL8325608 | 0.91 | MAPT (0.53) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| SCHEMBL8563378 | 0.90 | PDE4B (0.59) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| SCHEMBL8567052 | 0.89 | MAPT (0.55) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| Hydrochloric Acid SCHEMBL811230 | 0.89 | PDE4B (0.58) | MAPTNPC1SMN1; SMN2PDE4BTP53 | |
| Hydrochloric Acid SCHEMBL8566227 | 0.88 | MAPT (0.54) | MAPTNPC1SMN1; SMN2PDE4BTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |