Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 10/20 | 0.89 |
| ▸ | FNTB | P49356 | 10/20 | 0.89 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334563 | 1.00 | FNTA (0.89) | FNTAFNTBOPRK1CYP3A4CYP2C19 | |
| SCHEMBL8331731 | 0.94 | FNTA (1.00) | FNTAFNTBOPRK1 | |
| SCHEMBL8332904 | 0.89 | FNTA (0.70) | FNTAFNTBOPRK1CYP3A4CYP2C19 | |
| SCHEMBL8332984 | 0.89 | FNTA (0.70) | FNTAFNTBCYP3A4CYP2C19TSHR | |
| SCHEMBL8332906 | 0.89 | FNTA (0.70) | FNTAFNTBOPRK1CYP3A4CYP2C19 | |
| SCHEMBL8330402 | 0.89 | FNTA (0.89) | FNTAFNTBOPRK1CYP3A4CYP2C19 | |
| SCHEMBL8332985 | 0.89 | FNTA (0.70) | FNTAFNTBCYP3A4CYP2C19TSHR | |
| SCHEMBL9074248 | 0.88 | FNTA (0.68) | FNTAFNTBCYP3A4CYP2C19TSHR | |
| SCHEMBL9074244 | 0.88 | FNTA (0.68) | FNTAFNTBCYP3A4CYP2C19TSHR | |
| SCHEMBL8335730 | 0.87 | FNTA (0.68) | FNTAFNTBCYP3A4CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783318-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-10-20 | — | — | EP | claimed |
| EP-0783318-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | claimed |
| WO-1996009836-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | claimed |
| EP-0783318-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-10-20 | — | — | EP | disclosed |
| EP-0783318-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5585359-A | LACK OF THIOL MOIETY PREVENTS THIOL-DEPENDENT CHEMICAL REACTIONS AND REDUCES SYSTEMIC TOXICITY | MERCK & CO., INC. (US) | 1996-12-17 | — | — | US | disclosed |
| WO-1996009836-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |