SCHEMBL8329610

SCHEMBL8329610

CC1=C(C(=O)O)C(c2cccc([N+](=O)[O-])c2)N(C)C(=O)N1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 7/20 0.58
CACNA1D Q01668 7/20 0.58
CACNA1S Q13698 7/20 0.58
CACNA1C Q13936 7/20 0.58
ADORA3 P0DMS8 1/20 0.54
POLB P06746 2/20 0.52
PDE1C Q14123 1/20 0.52
CACNA1B Q00975 1/20 0.51
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
HIF1A Q16665 3/20 0.50
LMNA P02545 2/20 0.50
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
MAPT P10636 2/20 0.50
MAPK1 P28482 1/20 0.50
GPR55 Q9Y2T6 1/20 0.50
CYP2D6 P10635 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9871899 0.88 CACNA1F (0.60) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7265084 0.87 CACNA1F (0.66) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9814257 0.85 CACNA1B (0.52) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10359266 0.85 CACNA1C (0.75) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7267141 0.85 CACNA1F (0.63) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7275064 0.83 CACNA1F (0.61) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL7265537 0.83 CACNA1F (0.63) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9476160 0.83 CACNA1F (0.67) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9478573 0.83 CACNA1F (0.64) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10639282 0.82 CACNA1F (0.50) CACNA1FCACNA1DCACNA1SCACNA1CADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5889016-A Dihydropyrimidone derivatives as NPY antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 1999-03-30 US disclosed
EP-0236902-A1 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-substituted-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters E.R. Squibb & Sons, Inc. (US) 1987-09-16 EP disclosed
US-4684655-A 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure E. R. SQUIBB & SONS, INC. (US) 1987-08-04 US disclosed