Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.58 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | CCKAR | P32238 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL833425 | 0.92 | PTGDR2 (0.56) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL831435 | 0.92 | PTGDR2 (0.56) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL831436 | 0.92 | PTGDR2 (0.56) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL832438 | 0.89 | PTGDR2 (0.55) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL832437 | 0.89 | PTGDR2 (0.55) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL832491 | 0.89 | PTGDR2 (0.55) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL833150 | 0.89 | PTGDR2 (0.57) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL833827 | 0.89 | PTGDR2 (0.57) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL833151 | 0.89 | PTGDR2 (0.57) | PTGDR2TBXA2RPTGDRKDM4EMEN1 | |
| SCHEMBL833576 | 0.88 | PTGDR2 (0.65) | PTGDR2TBXA2RPTGDRKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143304-B2 | (3-amino-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)-acetic acid derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2012-03-27 | — | — | US | disclosed |
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |