SCHEMBL8334302

SCHEMBL8334302

Bc1ccccc1C1=CCCN(c2nc(-c3ccncc3)cc(=O)n2C)C1

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 20/20 0.53
CYP1A2 P05177 3/20 0.53
CYP2D6 P10635 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2848974 0.89 GSK3B (0.56) GSK3BCYP1A2CYP2D6
SCHEMBL8334429 0.89 GSK3B (0.54) GSK3BCYP1A2CYP2D6
SCHEMBL2860273 0.88 GSK3B (0.58) GSK3BCYP1A2CYP2D6
SCHEMBL2854427 0.88 GSK3B (0.57) GSK3BCYP1A2CYP2D6
SCHEMBL2851781 0.88 GSK3B (0.57) GSK3BCYP1A2CYP2D6
SCHEMBL2851122 0.88 GSK3B (0.59) GSK3BCYP1A2CYP2D6
SCHEMBL8338072 0.87 GSK3B (0.59) GSK3BCYP1A2CYP2D6
SCHEMBL8337312 0.87 GSK3B (0.52) GSK3BCYP1A2CYP2D6
SCHEMBL8335581 0.86 GSK3B (0.52) GSK3BCYP1A2CYP2D6
SCHEMBL2851456 0.86 GSK3B (0.58) GSK3BCYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004055007-A1 3-SUBSTITUTED-4-PYRIMIDONE DERIVATIVES MITSUBISHI PHARMA CORPORATION (JP) 2004-07-01 WO disclosed