Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 18/20 | 0.81 |
| ▸ | CDK5R1 | Q15078 | 18/20 | 0.81 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.52 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5901589 | 0.90 | CDK5 (1.00) | CDK5CDK5R1CDC7DBF4 | |
| SCHEMBL5902520 | 0.90 | CDK5 (1.00) | CDK5CDK5R1 | |
| SCHEMBL5901436 | 0.89 | CDK5 (0.81) | CDK5CDK5R1 | |
| SCHEMBL5901418 | 0.88 | CDK5 (1.00) | CDK5CDK5R1 | |
| SCHEMBL5902249 | 0.88 | CDK5 (0.81) | CDK5CDK5R1 | |
| SCHEMBL5902427 | 0.86 | CDK5 (0.85) | CDK5CDK5R1 | |
| SCHEMBL5901946 | 0.85 | CDK5 (0.76) | CDK5CDK5R1 | |
| SCHEMBL5902548 | 0.85 | CDK5 (0.75) | CDK5CDK5R1 | |
| SCHEMBL5902209 | 0.85 | CDK5 (1.00) | CDK5CDK5R1 | |
| SCHEMBL5901558 | 0.84 | CDK5 (0.81) | CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004060890-A1 | 2-OXOPYRIDIN-3-YL THIA (DI) AZOLE DERIVATES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | AMGEN INC. (US) | 2004-07-22 | — | — | WO | disclosed |