Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.58 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.58 |
| ▸ | CTSD | P07339 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342809 | 0.87 | BACE2 (0.75) | BACE1BACE2CTSDAPP | |
| SCHEMBL13679225 | 0.87 | BACE2 (0.75) | BACE1BACE2CTSDAPP | |
| SCHEMBL14253014 | 0.87 | BACE2 (0.75) | BACE1BACE2CTSDAPP | |
| SCHEMBL14253009 | 0.87 | BACE2 (0.75) | BACE1BACE2CTSDAPP | |
| SCHEMBL8336934 | 0.87 | BACE2 (0.75) | BACE1BACE2CTSDAPP | |
| SCHEMBL14263068 | 0.87 | BACE2 (0.75) | BACE1BACE2CTSDAPP | |
| SCHEMBL14262983 | 0.87 | BACE2 (0.75) | BACE1BACE2CTSDAPP | |
| SCHEMBL8339883 | 0.87 | BACE2 (0.75) | BACE1BACE2CTSDAPP | |
| SCHEMBL8339143 | 0.84 | BACE2 (0.76) | BACE1BACE2CTSDAPP | |
| SCHEMBL14262895 | 0.84 | BACE2 (0.76) | BACE1BACE2CTSDAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043916-A1 | PHENYLCARBOXAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2004-05-27 | — | — | WO | disclosed |