Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 11/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040488 | 0.87 | HCRTR2 (1.00) | HCRTR2ALDH1A1KEAP1NFE2L2TSHR | |
| SCHEMBL1039054 | 0.87 | HCRTR2 (0.77) | HCRTR2ALDH1A1KEAP1NFE2L2TSHR | |
| SCHEMBL1039401 | 0.85 | HCRTR2 (0.74) | HCRTR2ALDH1A1KEAP1NFE2L2TSHR | |
| SCHEMBL1039013 | 0.85 | HCRTR2 (1.00) | HCRTR2ALDH1A1KEAP1NFE2L2TSHR | |
| SCHEMBL1039891 | 0.81 | HCRTR2 (0.73) | HCRTR2ALDH1A1KEAP1NFE2L2MAPT | |
| SCHEMBL1041090 | 0.81 | HCRTR2 (1.00) | HCRTR2ALDH1A1KEAP1NFE2L2CNR1 | |
| SCHEMBL1040064 | 0.81 | HCRTR2 (0.73) | HCRTR2ALDH1A1KEAP1NFE2L2NPSR1 | |
| SCHEMBL1037275 | 0.81 | HCRTR2 (0.72) | HCRTR2ALDH1A1KEAP1NFE2L2MAPT | |
| SCHEMBL8340688 | 0.79 | HCRTR2 (0.64) | HCRTR2ALDH1A1KEAP1NFE2L2HCRTR1 | |
| SCHEMBL1040574 | 0.79 | HCRTR2 (0.65) | HCRTR2ALDH1A1KEAP1NFE2L2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-B1 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-01-26 | — | — | EP | disclosed |
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |