Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954191 | 0.84 | GAA (0.57) | GAAHPGDLMNAL3MBTL1PLK1 | |
| SCHEMBL3130427 | 0.82 | HIF1A (0.54) | GAAHPGDLMNAL3MBTL1HTT | |
| SCHEMBL6868432 | 0.82 | HPGD (0.66) | GAAHPGDLMNAL3MBTL1PLK1 | |
| SCHEMBL14429809 | 0.82 | HPGD (0.43) | GAAHPGDLMNAL3MBTL1HTT | |
| Hydrochloric Acid SCHEMBL29444036 | 0.81 | HIF1A (0.53) | GAAHPGDLMNAL3MBTL1HTT | |
| SCHEMBL16597336 | 0.81 | GAA (0.53) | GAAHPGDLMNAL3MBTL1PLK1 | |
| SCHEMBL4019795 | 0.81 | HPGD (0.45) | HPGDALDH1A1KDM4EBRD4BCAT2 | |
| SCHEMBL4763592 | 0.81 | GAA (0.53) | GAAHPGDLMNAL3MBTL1PLK1 | |
| SCHEMBL17629659 | 0.81 | GAA (0.53) | GAAHPGDLMNAL3MBTL1PLK1 | |
| SCHEMBL19495003 | 0.81 | SLC6A4 (0.42) | GAAHPGDLMNAL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |