Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339638 | 0.86 | GSK3B (0.62) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8342397 | 0.84 | GSK3B (0.57) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8342557 | 0.83 | MAPT (0.53) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8344608 | 0.83 | MAPT (0.56) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8342652 | 0.82 | MAPT (0.64) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8344257 | 0.82 | GSK3B (0.58) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15086956 | 0.80 | MAPT (0.52) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13790429 | 0.78 | MEN1 (0.60) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8344088 | 0.76 | GSK3B (0.80) | GSK3B | |
| SCHEMBL28393556 | 0.75 | MAPT (0.65) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |