Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326433 | 0.98 | PARP10 (0.58) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL15830297 | 0.98 | PARP10 (0.58) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL7317661 | 0.94 | PARP10 (0.54) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL16147114 | 0.93 | EPHX2 (0.61) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL13266896 | 0.88 | EPHX2 (0.57) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL7659739 | 0.85 | EPHX2 (0.52) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL239876 | 0.85 | HRH1 (0.53) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL31114566 | 0.85 | EPHX2 (0.55) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL1707168 | 0.85 | MEN1 (0.54) | PARP10CA1CA2EPHX2FAAH | |
| SCHEMBL3023506 | 0.84 | ACACB (0.58) | PARP10CA1CA2EPHX2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908859-A | ESPECIALLY HYPERCHOLESTEROLEMIA | ELI LILLY AND COMPANY (US) | 1999-06-01 | — | — | US | disclosed |
| EP-0897918-A1 | Benzothiophene derivatives and their use as pharmaceutically active agents | ELI LILLY AND COMPANY (US) | 1999-02-24 | — | — | EP | disclosed |
| WO-1999007694-A1 | COMPOUNDS AND USES THEREOF | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |
| US-4075227-A | NONSTEROIDAL | ELI LILLY AND COMPANY (US) | 1978-02-21 | — | — | US | disclosed |