Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205168 | 0.93 | GSK3B (0.61) | GSK3BPIK3CDMAPTSRCPI4KA | |
| SCHEMBL6227233 | 0.87 | GSK3B (0.59) | GSK3BMAPTSRCPI4KAPI4K2B | |
| SCHEMBL6251627 | 0.84 | GSK3B (0.66) | GSK3BMAPTSRCPI4KAPI4K2B | |
| SCHEMBL8338999 | 0.81 | GSK3B (0.61) | GSK3BPIK3CDMAPTSRCPI4KA | |
| SCHEMBL8344435 | 0.78 | GSK3B (1.00) | GSK3B | |
| SCHEMBL8339313 | 0.77 | GSK3B (0.82) | GSK3B | |
| SCHEMBL6207166 | 0.76 | GSK3B (0.66) | GSK3BMAPTSRCPI4KAPI4K2B | |
| SCHEMBL8344653 | 0.74 | GSK3B (0.78) | GSK3B | |
| SCHEMBL839950 | 0.73 | SLC2A1 (0.60) | GSK3BMAPTLMNAHSD17B10RAB9A | |
| SCHEMBL22604319 | 0.71 | SRC (0.50) | GSK3BSRCPI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |