SCHEMBL8340275

SCHEMBL8340275

CN1CC[C@@H](Oc2cc(NS(=O)(=O)c3cc(Br)c(Sc4ccc(F)cc4)s3)ccc2Cl)C1

nearest known ligand 0.61

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 16/20 0.61
HTR2C P28335 1/20 0.39
HTR2B P41595 1/20 0.39
SCN1A P35498 1/20 0.36
SCN8A Q9UQD0 1/20 0.36
HTR6 P50406 1/20 0.36
ERBB2 P04626 1/20 0.35
EPHA2 P29317 1/20 0.35
KDR P35968 1/20 0.35
EPHB4 P54760 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6820377 0.90 UTS2R (0.62) UTS2RHTR2CHTR6ERBB2EPHA2
SCHEMBL6821337 0.90 UTS2R (0.62) UTS2R
SCHEMBL6821343 0.90 UTS2R (0.62) UTS2R
SCHEMBL5741755 0.85 UTS2R (0.69) UTS2RHTR6ERBB2EPHA2KDR
SCHEMBL5744180 0.85 UTS2R (0.69) UTS2RHTR6ERBB2EPHA2KDR
SCHEMBL5741757 0.85 UTS2R (0.69) UTS2RHTR6ERBB2EPHA2KDR
SCHEMBL6824520 0.85 UTS2R (0.58) UTS2R
SCHEMBL6824516 0.85 UTS2R (0.58) UTS2R
SCHEMBL5742992 0.84 UTS2R (0.68) UTS2RHTR6ERBB2EPHA2KDR
SCHEMBL5742998 0.84 UTS2R (0.68) UTS2RHTR6ERBB2EPHA2KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed