SCHEMBL8340588

SCHEMBL8340588

C=C(O)Cc1ccc(OCc2nc(-c3ccco3)oc2C)c(OC)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.60
SMN1; SMN2 Q16637 5/20 0.50
HSD17B10 Q99714 5/20 0.50
MAPT P10636 5/20 0.50
KDM4E B2RXH2 5/20 0.50
ALDH1A1 P00352 4/20 0.50
TSHR P16473 3/20 0.50
HPGD P15428 2/20 0.50
LMNA P02545 3/20 0.44
ALOX15 P16050 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
PPARA Q07869 2/20 0.42
TP53 P04637 2/20 0.40
MAPK1 P28482 2/20 0.40
MEN1 O00255 1/20 0.40
NFKB1 P19838 1/20 0.40
NFKB2 Q00653 1/20 0.40
KMT2A Q03164 1/20 0.40
RELA Q04206 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4850543 0.91 PPARG (0.61) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL4035637 0.89 PPARG (0.62) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL6583254 0.88 PPARG (0.66) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL1732725 0.87 PPARG (0.62) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL6585691 0.85 PPARG (0.68) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL4850848 0.85 PPARG (0.58) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL6584001 0.84 PPARG (0.67) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL4852628 0.83 PPARG (0.56) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL1731572 0.83 PPARG (0.58) PPARGSMN1; SMN2HSD17B10MAPTKDM4E
SCHEMBL6582015 0.82 PPARG (0.61) PPARGSMN1; SMN2HSD17B10MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5965589-A AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-12 US disclosed
EP-0783496-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-16 EP disclosed
WO-1996005186-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-02-22 WO disclosed